The innate immune response constitutes the body’s first line of defence against pathogens, utilising a network of pattern recognition receptors (PRRs) and signalling molecules to detect and neutralise ...

The Bacille Calmette–Guérin (BCG) vaccine, originally developed for tuberculosis prevention, has garnered considerable attention for its capacity to reprogramme the innate immune system. Beyond its ...

There is significant crosstalk between DNA damage response (DDR) pathways and innate immune pathways. Both the individual pathways and their interactions are key areas of interest for the development ...

Damaging variants in genes involved in a rapid immune response (innate immunity) are significantly linked to earlier breast ...

A section of Goodsell et al.’s magnificent “Integrative illustration for coronavirus outreach” highlighting the packaging of the viral genetic material (in pink) by the scaffold “nucleocapsid protein” ...

Damaging variants in genes involved in a rapid immune response (innate immunity) are significantly linked to earlier breast ...

When a transplanted organ arrives, it’s like a controlled burn that risks becoming a wildfire. The body’s innate immune system senses damage signals, like heat shock proteins (HSP70), and sounds the ...

For decades, dogma dictated that the immune system consisted of two separate branches. Cells of the innate system respond rapidly to molecular patterns shared by a broad array of pathogens. Meanwhile, ...

UT Southwestern Medical Center researchers have identified how the quintessential immune protein known as stimulator of ...

The immune system can work in two ways: the innate immune system reacts to any foreign invaders that are identified by immune cells that look for such pathogens; but the acquired or adaptive immune ...

Macrophages, the immune system’s front-line scavenger cells, do more than simply digest dead cells. A new study published in ...